Anti-Human respiratory syncytial virus (RSV) Glycoprotein G/RSV-G Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: E-AB-V1274-50, E-AB-V1274-100

Citations, Manuals and MSDS Available upon request.

Target Synonym: G; Glycoprotein

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: RSV

Application: ELISA

Isotype: IgG1

Clonality: Monoclonal

Clone No.: 9H2G5C6

Background: Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.

Concentration: 1mg/mL

Immunogen: Recombinant RSV (A, rsb1734) glycoprotein G / RSV-G Protein (95% Homology) (His Tag)

Buffer: 0.2 μm filtered solution in PBS

Purification Method: Protein A Affinity

Dilution: ELISA 1:1000-1:2000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only